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10.1016/S1474-4422(10)70212-X [DOI] [PubMed] [Google Scholar] Kelm-Nelson C

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Maximum serum radioactivity occurs at 1 to 2 hours after oral 35S-azathioprine and decays with a half-life of 5 hours

At the same time, the extreme production of ROS impaired the degradation of Nrf2, which is mediated by kelch-like epichlorohydrin-associated protein 1 (Keap1) [80], resulting in the accumulation of Nrf2 that upregulated HO-1 production [81, 82], as confirmed in our study