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The decisions on how to classify ex-US sites, which waivers are applicable, and when to apply for them can be difficult and requirements associated with these waivers can be intimidating

A multicenter trial in Alzheimers disease found no benefit on cognitive or functional outcomes while shifting some biomarkers, a smaller trial in healthy older adults reported improved memory and hippocampal connectivity, and the overall assessment is that it is unlikely to help most healthy adults and that the evidence is not conclusive

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