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OLs are highly susceptible to damage during the acute phase of ischemia: OL and astrocyte swelling can be observed as early as 30 min post-stroke, with substantial OL death within 3 h (Pantoni et al., 1996)

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He F, Ru X, Wen T (2020) NRF2, a transcription factor for stress response and beyond

Theoretically, vaccines are synergistic with antioxidative stress, and the significance and value of modulating oxidative stress in preventing CAP in older individuals may be better realized on the basis of the low-grade chronic inflammatory state and the chronic accumulation of ROS in older individuals