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Cognition and physical function OA had significantly impaired cognition scores on the Montreal cognitiveassessments, trail making tests A and B, verbalfluency test and DSST, together with lower fasting plasma brain derived neurotropic factor (BDNF) level (Table 6) (Figure 2)

Oral supplementation: In some cases, where the deficiency is mild or once injection therapy has been completed, oral B12 supplements may be used for maintenance