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Impact of Imatinib Mesylate Dose Escalation on Resistance and Sub-Optimal Responses to Standard-Dose Therapy in Patients (pts) with Chronic Myeloid Leukemia (CML)

ROS increase epidermal growth factor receptor phosphorylation, providing binding sites for the Grb2-SOS complex, which activates RAS signaling (73)

Potential complications include infection, swelling, bruising, scarring, and changes in skin sensation, such as numbness or tingling

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