low glutathione and erectile dysfunction Oxidative Stress Dysfunction: Pathophysiology, Impacts, and Potential Treatments ERECTILE DYSFUNCTION (ED) - GloFusion

The radio-resistance of CSCs is associated with their low proteasome activity, which reduces the proteasome-dependent degradation of antioxidant-related molecules such as xCT, Nrf2, and ATF4, thereby leading to their intracellular accumulation 18,19,20 The cystine/glutamate antiporter xCT, also known as SLC7A11, is involved in GSH biosynthesis and maintains tumor redox status 21 In addition, the accumulation of transcription factors including Nrf2 and ATF4 promotes xCT expression, enhancing the cellular antioxidant capacity 19

209 Interestingly, ROS can inhibit pyroptosis through the PI3K/AKT-mTORC2 pathway, suppressing ASK1 activation

Tausz M., Sircelj H

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