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Side effects from B12 supplementation are uncommon but may include: Mild gastrointestinal symptoms such as nausea or diarrhoea, typically with very high oral doses Headache or dizziness in some individuals Skin reactions (rash, itching) at injection sites when using intramuscular preparations Rare but serious allergic reactions, including anaphylaxis with injectable forms Hypokalaemia (low potassium) may occur during rapid correction of severe megaloblastic anaemia If you experience symptoms of a severe allergic reaction (difficulty breathing, severe rash, swelling of face or throat) after taking B12, seek immediate medical attention

The short-chain amino acids serve as the building blocks of proteins and key signaling molecules in the body, helping regulate several functions, including immune response, muscle protein synthesis and hormonal cycles

Similarly, intrahippocampal infusions of IL-6 induced IDO1 expression, and inhibition of hippocampal IDO1 ameliorated depressive-like behavior in male rats [115]