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Pharmacological Basis of Therapeutics

Methods: The anti-senescence effects of PT were investigated in human dermal fibroblasts (HDFs) using models of UVB-induced acute oxidative stress and replicative senescence

FGF23 acts in opposition to GH by increasing phosphaturia via suppression of Na-Pi 2a and 2c expression in proximal tubules and decreasing renal calcitriol synthesis, whereas it shares its calcium-sparing effects by enhancing renal calcium reabsorption in the distal tubule [81]

It is of some interest that liver tumors in chlordane-treated mice, including some hepatocellular carcinomas, were shown to regress upon cessation of treatment, suggesting that their tumor response was conditional upon continued exposure to chlordane (Malarkey et al