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This enhanced penetration increases local antibiotic concentrations at infection sites and improves treatment efficacy [166, 167]

Mahrouf-Yorgov M, Augeul L, Da Silva CC, Jourdan M, Rigolet M, Manin S, Ferrera R, Ovize M, Henry A, Guguin A, et al

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The sensitivity and variability of pyruvate dehydrogenase complex activity testing using cultured fibroblasts, WBC lymphocytes, or skeletal muscle tissue for other pyruvate dehydrogenase complex deficiency-associated genes remain to be thoroughly evaluated