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Through injection of -syn preformed fibrils (PFFs) into the striatum of transgenic mice, researchers demonstrated the development of Lewy pathology, nigrostriatal degeneration, and importantly expanded our understanding of cell-to-cell transmission by describing the nature of spread in neuroanatomically connected regions: this provided the first evidence that synthetic -syn PFFs alone can induce the initiation and propagation of -syn pathology in vivo (Luk et al., 2012)

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The process usually takes 30 to 60 minutes, during which patients can relax in a comfortable setting

Cleavage under targets and tagmentation (CUT&Tag) and data analysis The CUT&Tag experiments of DON-treated GCs were performed by Wuhan Frasergen Bioinformatics Co., Ltd