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Systemic inflammation has been linked to impaired cognitive function and aberrations in brain structure in many settings (refer to the Age-Related Cognitive Decline protocol for a more thorough discussion of the role of inflammation in cognitive dysfunction)

TBI treatment includes pharmacotherapy, cognitive therapies and surgeries, which depend on the severity of the condition (Stocchetti et al., 2017)

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4 Strengths and limitations This review integrates evidence across cellular, organ, and physiological levels, highlighting autophagy pathways, hormonal regulation involving GH, cortisol, insulin, leptin, and thyroid hormones, as well as cardiovascular, neurological, and gastrointestinal outcomes