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A particular point is a very safe profile (LD1 could be not achieved) [7,16], a point recently confirmed in a large study of the Xu and collaborators [83]

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Interestingly, the effects worked within the first three weeks and persisted even upon discontinuation of the patches

In agreement with our study, placentas from pregnant people with GDM show lower amounts of total ceramides and of C16:0, C18:0 and C24:0 ceramide species, possibly due to a decreased content of ASHA1, the enzyme responsible for ceramide catabolism into sphingosine and fatty acids (Reference Abbade, Klemetti and Farrell17)