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In the MET4-IO clinical trial, MET4 combined with ICIs demonstrated safety in advanced solid tumors and showed signs of efficacyincluding stable disease in 40% of patientsby reprogramming bile acid metabolism (elevating tauroursodeoxycholic acid) and enhancing CD8 + T cell infiltration (267)

Horber FF, Haymond MW

24 , e55678 (2023)

3.3.1 Preclinical evidence Preclinical studies demonstrate that metformin protects against diabetic cardiomyopathy (DCM) through multiple complementary mechanisms (Zhao et al., 2021