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Phase II study of high-dose amsacrine (AMSA) and autologous bone marrow transplantation in patients with refractory metastatic breast cancer

The primary ascertainment that we make to choose ideal candidates is test for normal kidney function

Additionally, NADPH, vital for cellular redox balance, is thought to influence both ferroptosis and necrosis, with its consumption during necrosis potentially sensitizing neighboring cells to ferroptosis due to reduced intracellular NADPH levels (121)