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In recent years, the hepatotoxicity of cantharidin has also been systematically investigated

Overall, PSC is a progressive disease that will lead to cirrhosis and associated complications

Mol Biol Cell 8 : 16991707

For instance, in M1 pro-inflammatory macrophages (Ms), there is a metabolic break at isocitrate dehydrogenase in the TCA cycle due to suppression of its mRNA expression, leading to the accumulation of citrate and itaconate, which drive lipid synthesis and stabilization of anti-inflammatory transcription factors, such as nuclear factor-erythroid factor 2-related factor 2 (NRF2) and activating transcription factor 3 (15)