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The results show that DAT trimerization is favored by inward-open conformation, involves the hydrophobic residues in the TM4 and TM9, and inhibitors like AIM-100 facilitate the transition from outward-open to inward-open conformation (Sorkina et al., 2021)

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GHK-Cu mechanism and discontinuation implications GHK-Cu functions through multiple mechanisms creating skin improvements, with discontinuation effects depending critically on whether peptide presence remains necessary for maintaining induced changes or whether improvements become self-sustaining after initial stimulation period

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