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To examine this notion, we prepared the linear -conotoxin SI peptide by solid phase peptide synthesis (SPPS), with two Cys (3&13) protected with the trityl PG to afford the free SH of these Cys residues after trifluoroacetic acid (TFA) cleavage, and two additionally modified Cys (2&7) with the (Acm) moiety, (Supplementary Fig

1158 Trimetazidine, a drug that restricts FAO by blocking the enzyme 3-ketoacyl-CoA thiolase while simultaneously promoting glucose oxidation, 1161 not only improves the cardiac energy supply but also may regulate cardiac function by reducing systemic resting energy expenditure