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Nitric oxide decreases cytokine-induced endothelial activation

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This is particularly relevant in diabetic conditions where elevated levels of ROS can lead to cellular damage and exacerbate neuropathic symptoms (Gonzlez-Burgos and Gmez-Serranillos, 2012)

Low GSH concentrations in H IV and other infections foster an oxidative environment conducive to disulfide formation and extensive protein folding in the viral proteins synthesized within the infected mononuclear cells/macrophages