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NCCN guidelines insights: central nervous system cancers, version 1.2017

Nrf2 impairment may be behind many mitochondrial disorders. Nrf2 is a key mitochondrial protector and stimulant of mitochondrial biogenesis. Nrf2 improves adipose cell differentiation. In animals, ozone preconditioning protects against heart ischemia-reperfusion injury via Nrf2 gene activation. OT modulates Nrf2 producing three key effects