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10.1021/acs.jafc.9b03092 26 ChenS.HendersonA.PetrielloM

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It is plausible that the lack of ergogenic effects could be attributed to the trained participant cohort in the cycling studies (VO 2peak range = 56.3 58.1 ml.kg 1 .min 1 ), such that a recent point-counterpoint debate suggests due to an elevated NO at baseline compared to their untrained counterparts this could blunt the ergogenic effect (Hultstrm et al

Importantly, while the incidence of adverse effects was similar between ALC and placebo/no intervention, ALC was associated with a lower incidence of adverse effects compared to antidepressant medications