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Description

One of the mechanisms of tumor cell resistance to chemotherapeutic drugs is the overexpression of MDR proteins, including MDR1 and MRP1, leading to increased drug efflux to reduce the intracellular drug accumulation and effective drug concentration at the target sites (18,19)

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"Cysteine/Glutathione Deficiency: A Significant and Treatable Corollary of Disease"

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Franke 2003)

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