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First, the neurovascular unit serves as a metabolic nexus, modulated by hepatic ketogenesis flooding the bloodstream with neuroprotective -hydroxybutyrate [10, 51], adipose lipolysis fueling inflammatory storms [12, 130], and skeletal muscle myokines influencing penumbral resilience [188]

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Commonly, initial treatment may involve weekly injections for a few weeks, followed by monthly maintenance doses as needed

Adjuvant properties are mainly provided by DAMPs, including ATP, HMGB1, CRT, HSPs and so on (82)