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Proc Natl Acad Sci USA (2018) 115(10):E23208

doi: 10.1146/annurev-biophys-111622-091309 28 KoppMCLarburuNDurairajVAdamsCJAliMMU

More importantly, based on the high H 2 O 2 of TME, the oxalate bond in the prodrug molecule is broken, thus the POD molecule with anti-tumor activity is controllably released, and tumor-specific treatment is realized