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61 demonstrated that NR supplementation altered the gut microbiome in mice and demonstrated that the gut microbiome change was able to impact weight gain in mice fed a high-fat diet

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Researchers using DEXA scans or waist circumference measurements often see disproportionate reductions in trunk fat compared to peripheral fat during this phase

For example, PLP is required for the synthesis of neurotransmitters such as GABA and serotonin, for heme biosynthesis (through -amino levulinate synthase in red blood cell production), and for amino acid transformations