nrf2 glutathione peroxidase plays a critical role in mitigating lipid peroxidation and ferroptosis Frontiers | Nrf2 and Ferroptosis:

During osteoclastogenesis, RANKL-induced ROS induced PGC-1 via activation of CREB, and PGC-1 increased the production of reactive oxygen species and mitochondrial biogenesis, leading to the induction of osteoclastogenesis through a positive feedback mechanism [11, 12, 44, 45]

Altogether, these results demonstrate that ALS-causative mutations in FUS/TLS acquire partial to nearly complete loss of normal function in regulating splicing

Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor gamma coactivator 1alpha

Cell cycle inhibitors disrupt tumor proliferation, while antibody therapies enhance tumor specificity