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In contrast to rAmy, Cagri primarily engages the CTR in a bypass conformation, equivalent to that observed when bound to AMYRs, with 85% of particles in the final particle stack stabilised in this conformation (Fig

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Key active ingredients include Acetyl-L-Carnitine and Alpha-Lipoic Acid

With an optimized vitrification procedure, we were able to achieve recovery of cellular metabolism and electrophysiology by patch-clamp recordings, and extracellular field postsynaptic potentials (fPSPs) including short-term and long-term synaptic plasticity