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Statistics analysis Statistical analysis was performed using GraphPad Prism 8.0 (GraphPad Software) and presented as means SEM

Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells

At timepoint 360 min, we observed a pronounced drop in both fully labeled glucose and lactate in iPSCs, most likely reflecting depletion of the extracellular glucose supply (5 mM) in the medium, which may have contributed to the onset of gluconeogenesis, highlighting a metabolic adaptation in response to nutrient availability [67]

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