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Although the first studies in this field began over 100 years ago, the investigation of peptides remains a key focus in modern pharmacology [4]

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It serves as a required substrate for enzymes such as sirtuins and poly(ADP-ribose) polymerases (PARPs). Sirtuins regulate cellular stress responses, metabolic homeostasis, and genomic stability, while PARPs play a central role in detecting DNA damage and initiating repair processes

James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH, Cutler P, Bock K, Boris M, Bradstreet JJ, et al