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Gilliam, L.A

The Zn 2+ ion plays a structural role and is required for an efficient SOD1 folding and long-term stability 2 , whereas active-site Cu 2+ catalyzes O 2 dismutation by alternating between the reduced and oxidized states (Reactions 1 and 2): In the nervous tissue, SOD1 is present at exceedingly high concentrations (~1% of total protein, i.e., 100200 M) 3 and is traditionally regarded as cytosolic protein 4

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Single-cell repertoire tracing identifies rituximab refractory B cells during myasthenia gravis relapses