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it is a quinolinium-class small molecule with a membrane-permeable structure designed for intracellular enzyme inhibition

Wei Z, et al

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33 All the calibrated model parameters were fixed and then only the strength of the inhibitors was fitted to the pAKt and pERK data from individual treatments with inhibitors of Met, PDK1, MEK, and PI3K, 33 and using these inhibition strength values and the fitted model we predicted the results of combination therapy (Supplementary Fig