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Aydin 1 , Jana Rieger 1 , Dimitrios Rallios 1,2 , Satoru Tanioka 1 , Charles Majoie 3 , Wim Van Zwam 4 , Aad van der Lugt 5 , Adam Hilbert 1 , Dietmar Frey 1,2 1 CLAIM - Charit Lab for Artificial Intelligence in Medicine, Charit Universittsmedizin Berlin, Germany, Berlin, Germany, 2 Department of Neurosurgery, Charit Universittsmedizin Berlin, Berlin, Germany, 3 Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 4 Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 5 Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands Background and Aims: Characterizing Circle of Willis anatomical variations and pathologies is critical for stroke treatment planning and prognosis

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This superficial location makes them vulnerable to repetitive strain but also makes them accessible for local treatment approaches

Targeting ATP7B-mediated copper efflux and sEV secretion thus represents a promising approach to restore cuproptosis sensitivity and overcome chemoresistance in refractory OSCC