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[22] Anti-cancer treatment [edit] SAM has recently been shown to play a role in epigenetic regulation

, l- 2000 / 3000 /

ISSN 1462-2416

Moving forward, the integration of biochemical reconstitution approaches, live-cell PTM biosensors, and spatiotemporal manipulation tools such as STRIP, together with the development of selective small-molecule modulators of glutamylation, will be essential for mapping this modification with high temporal and spatial precision and for establishing causal links between specific glutamylation patterns and defined cellular outputs