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A common scenario: you think you reconstituted at 10 mg/mL but actually used 5 mL instead of 6 mL of water, creating a 12 mg/mL solution

Conditions like pernicious anaemia, IBS, or gastric surgery can impair B12 absorption

This link was not seen in those with normal B12 levels ( Another study suggested that people with high folate and low vitamin B12 levels may be up to 3.5 times more likely to experience a loss of brain function than those with normal blood parameters ( However, keep in mind that more studies are needed before it can be said with certainty that supplementing with high amounts of folic acid could be detrimental to mental health

Even at high oral doses, only a small percentage is absorbed, which is part of why therapeutic doses look so large