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Our study found decreased HSPA12B expression and impaired GATA4 transcriptional activity in LSECs of NASH/cirrhosis patients, suggesting their contribution to NASH/cirrhosis associated hepatic immune dysfunction and increased susceptibility to bacterial infections

Connectivity Map (CMap) A database developed at the Broad Institute (MIT/Harvard) that maps how thousands of compounds alter gene activity across the human genome

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like skin rash, hives with itching and red swollen blistered peeling skin with or without fever, wheezing, tightness in the chest or throat, trouble breathing, trouble swallowing, trouble talking, unusual hoarseness, or swelling of the mouth, face, lips, tongue, or throat

The agarose was then incubated with purified His6-CRBN overnight following three PBS washes, and the samples underwent immunoblotting