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Dual targeting of Nur77 and AMPK by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo

DECLARATIONS Research in the authors lab has been supported by The University of Texas MD Anderson Cancer Center, National Institutes of Health grants R01CA181196, R01CA244144, and R01CA247992 (to BG), and Cancer Center Support (Core) Grant P30 CA016672 from the National Cancer Institute, National Institutes of Health (to The University of Texas MD Anderson Cancer Center)

871 Oxidative stress is characterized by MDA and 4-HNE, and their roles in cartilage degeneration and subchondral bone remodeling during OA development have received extensive attention

Patients with SCD have increased rates of venous and arterial thrombotic events ( Unraveling these pathophysiological targets has provided insights on clinical trials on anti-platelet and anti-adhesion agents, as well as anti-coagulation factors for the prevention of acute VOC pain in SCD (Telen, 2016