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The transactivation domain has been defined at the aa 486-691, which is highly acidic and contains numerous charged amino acids (Lukac et al., 1999

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Even though APOE isoforms did not cause changes in the expression levels of major glucose transporters of the brain, GLUT1, GLUT3 and GLUT4 [95], APOE can indirectly alter glucose uptake in an isoform-dependent manner