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Funding This research was supported by a grant from the Korean Health Technology R&D Project, the Ministry of Health and Welfare Republic of Korea (HI14C2357)

By contrast, the intrinsic pathway is driven by mitochondrial outer membrane permeabilization and loss of mitochondrial integrity, a process regulated by the Bcl-2 family of proteins

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NIK induces p100 processing through a posttranslational process triggered by site-specific phosphorylation of p100 at two C-terminal serine residues, S866 and S870 [5]