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Also sustaining this hypothesis, other authors observed that modulation of IGF-1R-associated genes promoted regulatory clustering as well as stemness and chemoresistance in cells from colorectal cancer patients and mouse models, and was facilitated by a master transcriptional regulator responsive to ribosomal dysfunction, PR domain zinc finger protein 1 (PRDM1) (49)

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This observation is in agreement with previous findings by Seong et al., who reported that exosomes could help manage glaucoma by lowering IOP [63]

coli , an unrelated bacterium, was used as an additional negative control to further assess the specificity of Apta9 and Apta10 for Borrelia