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While subcutaneous injection into the lower limbs may be possible, it is generally not recommended as a preferred injection site due to the possible complications involved including tissue damage and injection site reactions: The skin in the lower limbs is typically thinner and more sensitive than other parts of the body, which can increase the risk of pain, bleeding, and infection

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Health Library How To Give An Intramuscular Injection Our Services Learn why NewYork-Presbyterian is top ranked in 14 adult medical specialties and 8 pediatric subspecialties

If you're taking antibiotics such as chloramphenicol, colchicine, folic acid, methotrexate, and para-aminosalicylic acid, your doctor may have to monitor your condition for any possible side effects