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doi: 10.3389/fimmu.2019.03094 Received 27 September 2019 Accepted 18 December 2019 Published 10 January 2020 Volume 10 - 2019 Edited by Allen Jay Rosenspire, Wayne State University, United States Reviewed by agla Tkel, Temple University, United States

PMID: 35729801 J Med ChemStructural Optimization and Structure-Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6 H-pyrimido[5,4- b][1,4]oxazin-7(8 H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

The transition from animal studies to human populations is often complicated by differences in biological systems, making it difficult to directly translate animal-based results into practical human therapies