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However, G6PD reportedly undergoes modifications such as phosphorylation at Y112 and Y428 [69, 70] in HCT116 cells, acetylation at K403 [71] in leukaemia cells and glycosylation at S84 in lung cancer cells [72]

doi: 10.14309/ctg.0000000000000316

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Note that it may take 2-4 weeks for the full benefits of L-Citrulline to become apparent, although nitric oxide production leading to increased blood flow should be noticeable within hours