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The Critical Caveat All of the above is based largely on animal studies

Spence JD

In extreme cases, lack of B12 can damage the optic nerve or plug up the blood vessels in the retina, causing blurry vision, double vision, sensitivity to light, and even vision loss

For example, in contracting skeletal muscle tissue, the sarcoplasmic reticulum Ca 2+ -ATPase (SERCA) facilitates calcium reuptake into the reticulum, preventing calcium overload in the sarcoplasmlikely in synergy with HSPA5 (Mzala et al., 2024)