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Furthermore, as one can clearly see, 100mg would cause potentially supraphysiological levels on average, as 50mg elicits as high as 680ng/dL, or 23.6 nmol/L

However, every one of these analogues of vitamin B12 is recognized as vitamin B12 in all the serum B12 analyses, because the assays do not distinguish the analogue of vitamin B12, rather measure the absolute amount of ANY of the analogues

We therefore conclude that transcriptional repression by promoter hypermethylation was not the primary regulatory effect of the altered methylation marks, but the findings indicate a global disruption of DNA methylation mechanisms

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