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Stephanie Nielsen, PharmD, CCN, CFGP, functional genomic practitioner at The DNA Company

Kristan MM, Toro-Tobon D, Francis N, Desale S, Bikas A, Jonklaas J, et al

Major cyclic regulator of melatonin generation in pineal gland is prevailing light/dark environment (1-3), activating the anterior hypothalamus via the axons of retinal ganglion cells running in the optic nerves and forming retino-hypothalamic tract to reach the SCN that are connected with pineal gland through paraventricular nuclei, preganglionic sympathetic neurons, innervating superior cervical ganglia and then postsynaptic sympathetic neurons supplying pineal gland ( Fig