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doi: 10.3390/ijms20020319 179 ChenHLiuSGeBZhouDLiMLiWet al

A similar mechanism has been described for the prion protein PrP, wherein its mislocalization to the cytosol enables aberrant binding to cytosolic ubiquitin ligase, sequestering the enzyme and reducing its functional availabilitythereby contributing to neurodegeneration 82