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The evidence available to assess either sodium thiosulfate or hydroxocobalamin is incomplete

These were then selected further using the one-way analysis of variance (ANOVA) test, followed by a correction for multiple comparisons by controlling the false discovery rate with the two-stage step-up method of Benjamini, Krieger, and Yekutieli, as recommended by the GraphPad Prism software (version 7.0 for Mac OS X)

Study 3 An extension study (Study 261302, NCT01945593) in adult and pediatric patients evaluated the safety and efficacy of prophylactic treatment regimen in 216 previously treated patients with severe hemophilia A