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Likewise, to avoid unpleasant side effects of systemic carbonic anhydrase inhibition, carbonic anhydrase inhibitors, since acetazolamide (topical administration with little or no effect on intraocular pressure) [68,69], were used for a long period before a topical carbonic anhydrase inhibitor was realized (dorzolamide) [70,71]

While Semax has clinical history in Russia, the English-language human evidence base remains limited , so it should be approached with clear expectations, careful screening, and clinician-guided riskbenefit review

Option (Evidence Strength: Grade C) If Hunner lesions are present, then fulguration (with laser or electrocautery) and/or injection of triamcinolone should be performed

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