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This leads to the formation of regenerative hepatic nodules encased in dense fibrous tissue, containing significantly higher levels of extracellular matrix proteins, particularly collagen types I, III, and IV, which hinder portal blood flow and elevate portal pressure, ultimately culminating in clinically significant portal hypertension in later disease stages (1)

Normalization method that resulted with a normal distribution of the data was chosen and varied between datasets (Supplementary Data 1)

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Chick embryos show a high requirement for L-carnitine, yet contain low levels of Lcarnitine, the injection of L-carnitine into the yolk sac would lead to circulation to fat storage areas such as the yolk sac to facilitate catabolism of fatty acids for energy