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These modifications dramatically reduce binding affinity to IGF-binding proteins (IGFBPs) the regulatory proteins that normally sequester and deactivate circulating IGF-1

Hire et al, (1992) Plant Mol Biol 20:207-18, Kuster et al, (1995) Plant Mol Biol 29:759-72, and Capana et al., (1994) Plant Mol Biol 25:681 -91

Glutaminolysis perturbations alter energy metabolism gene sets To understand how altered glutamine turnover affects white fat cell function, we targeted GLS , which encodes the rate-limiting enzyme in glutaminolysis 8