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Tumor hypoxia: from basic knowledge to therapeutic implications

10.1016/J.BBADIS.2018.03.007 47 dErricoP.Ziegler-WaldkirchS.AiresV.HoffmannP.MezC.ErnyD.et al (2021)

Moreover, recent study found that hypoxia-inducible factor (HIF)1 and HIF-2 in GBM cells jointly mediate upregulation of the mRNA and protein expression levels of the BCAAs transporter LAT 1 and the BCAAs metabolizing enzyme BCAT1, and ultimately promote the growth of cells under hypoxia conditions